Adenosine triphosphate facilitates the Na+-K pump of frog skeletal muscle fibres.

نویسندگان

  • K Kaibara
  • M Kojima
  • K Koketsu
  • T Akasu
  • M Miyagawa
  • K Hirai
  • T Tokimasa
  • H Hasuo
  • M Yamada
  • T Nishimura
چکیده

Effects of adenosine triphosphate (ATP) and dibutyryl cyclic adenosine monophosphate (dbc AMP) on the Na+-K+ pump of cell membrane were studied by testing the effects of these nucleotides on the 22Na+-efflux from frog skeletal muscle fibres. The rate coefficient of 22Na+-efflux was found to be significantly increased by ATP 3 mM. Dbc AMP 3 mM showed no demonstrable effect. These results support the concept that ATP facilitates the electrogenic Na+ pump, but do not support the concept that the electrogenic Na+ pump is stimulated by cyclic AMP.

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عنوان ژورنال:
  • The Kurume medical journal

دوره 28 2  شماره 

صفحات  -

تاریخ انتشار 1981